MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1400 to 1449 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.62709	up	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	cytoplasmic vesicle	cellular component
			dephosphorylation	biological process
			hydrolase activity	molecular function
			phosphoric monoester hydrolase activity
			protein amino acid dephosphorylation	biological process
			protein tyrosine phosphatase activity	molecular function
1.63639		Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]	biological_process	biological process
			cellular_component	cellular component
			cytoplasmic vesicle
			Golgi apparatus
			Golgi-associated vesicle
			molecular_function	molecular function
			plasma membrane	cellular component
1.63713		Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]	binding	molecular function
			integral to membrane	cellular component
			membrane
1.6384		Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]	G-protein coupled receptor protein signaling pathway	biological process
			integral to membrane	cellular component
			membrane
			olfactory receptor activity	molecular function
			receptor activity
			rhodopsin-like receptor activity
			signal transduction	biological process
1.63945		Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK). [Uniprot/SWISSPROT;Acc:P31152]	ATP binding	molecular function
			cell cycle	biological process
			MAP kinase activity	molecular function
			nucleotide binding
			protein amino acid phosphorylation	biological process
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
1.65422		Uncharacterized protein C9orf117. [Uniprot/SPTREMBL;Acc:Q5JU67]	intracellular	cellular component
			signal transduction	biological process
1.65835	down	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	cytoplasm	cellular component
			GTP binding	molecular function
			GTPase activity
			nucleotide binding
			nucleus	cellular component
			selenocysteine incorporation	biological process
			translation elongation factor activity	molecular function
			translational elongation	biological process
			tRNA binding	molecular function
1.66123	up	KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]	G-protein coupled receptor protein signaling pathway	biological process
			intracellular	cellular component
			membrane
			muscarinic acetylcholine receptor activity	molecular function
			nucleic acid binding
			regulation of transcription, DNA-dependent	biological process
1.66679		TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	metal ion binding	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.