MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

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Showing element 1340 to 1389 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.60746	down	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]	molecular function	DNA binding
				helicase activity
				hydrolase activity
				nucleic acid binding
				nucleotide binding
				tetracycline:hydrogen antiporter activity
1.61347		Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]	biological process	ciliary or flagellar motility
				epidermis development
				signal transduction
			cellular component	flagellin-based flagellum
			molecular function	calcium ion binding
				protein binding
1.61673	up	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]	biological process	protein amino acid phosphorylation
			cellular component	cytoplasm
				nucleus
			molecular function	ATP binding
				calcium ion binding
				calmodulin binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
1.61987		Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	biological process	activation of MAPKK activity
				anatomical structure morphogenesis
				apoptosis
				blood coagulation
				caspase activation
				cell motility
				elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
				establishment of synaptic specificity at neuromuscular junction
				G-protein coupled receptor protein signaling pathway
				multicellular organismal development
				negative regulation of neuron apoptosis
				positive regulation of calcium ion transport
				positive regulation of cell proliferation
				positive regulation of I-kappaB kinase/NF-kappaB cascade
				positive regulation of smooth muscle contraction
				positive regulation of vasoconstriction
				protein kinase C activation
				regulation of progression through cell cycle
				regulation of sensory perception of pain
				release of sequestered calcium ion into cytosol
				response to wounding
				signal transduction
				STAT protein nuclear translocation
				tyrosine phosphorylation of STAT protein
			cellular component	Golgi apparatus
				integral to membrane
				integral to plasma membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.