MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1190 to 1239 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.49558	down	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	molecular function	protein binding
				transforming growth factor beta receptor binding
1.49923		Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	biological process	blood vessel development
				cell-cell adhesion
				platelet-derived growth factor receptor signaling pathway
				regulation of small GTPase mediated signal transduction
				signal transduction
				small GTPase mediated signal transduction
				transmembrane receptor protein tyrosine kinase signaling pathway
			cellular component	intracellular
			molecular function	guanyl-nucleotide exchange factor activity
				protein binding
1.50206	up	LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]	biological process	ceramide biosynthetic process
				lipid biosynthetic process
				regulation of transcription, DNA-dependent
			cellular component	endoplasmic reticulum
				integral to membrane
				membrane
				nucleus
			molecular function	sequence-specific DNA binding
				transcription factor activity
1.50284	down	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	biological process	intracellular protein transport
				protein complex assembly
				transport
				vesicle-mediated transport
			cellular component	cytoplasmic vesicle
				Golgi apparatus
				membrane
				membrane coat
			molecular function	protein binding
				protein transporter activity
1.50715		F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Uniprot/SWISSPROT;Acc:Q969U6]	biological process	ubiquitin cycle
			molecular function	protein binding
1.51342		Beta-defensin 2 precursor (BD-2) (hBD-2) (Defensin, beta 2) (Skin- antimicrobial peptide 1) (SAP1). [Uniprot/SWISSPROT;Acc:O15263]	biological process	chemotaxis
				defense response
				defense response to bacterium
				G-protein coupled receptor protein signaling pathway
				immune response
			cellular component	extracellular region
1.5415		Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Uniprot/SWISSPROT;Acc:Q86SQ0]	biological process	chloride transport
				intracellular signaling cascade
				signal transduction
			cellular component	cytoplasm
				membrane
			molecular function	phospholipase C activity
				voltage-gated chloride channel activity
1.54317	up	Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Uniprot/SWISSPROT;Acc:Q9Y673]	biological process	determination of left/right symmetry
				protein amino acid glycosylation
			cellular component	endoplasmic reticulum
				integral to membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.