MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1143 to 1192 of 2667 in total

Regulation	Ratio	description	Gene Ontology	Class
down	5.84607	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	protein folding	biological process
			protein modification process
	6.3909	Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	apoptosis
			cytoplasm	cellular component
			intracellular signaling cascade	biological process
			metal ion binding	molecular function
			negative regulation of cell growth	biological process
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			response to stress
			transcription
			zinc ion binding	molecular function
	6.56408	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	DNA-directed RNA polymerase activity
			DNA-directed RNA polymerase III complex	cellular component
			nucleoplasm
			nucleus
			protein binding	molecular function
			transcription	biological process
			transcription from RNA polymerase III promoter
	7.45006	MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	G-protein coupled receptor protein signaling pathway
			histamine receptor activity	molecular function
			integral to membrane	cellular component
			structural constituent of cell wall	molecular function
up	1.07618	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	G-protein coupled receptor protein signaling pathway	biological process
			integral to membrane	cellular component
			metal ion binding	molecular function
			nucleic acid binding
			nucleotide binding
			nucleus	cellular component
			rhodopsin-like receptor activity	molecular function
			ribonucleoprotein complex	cellular component
			RNA binding	molecular function
			RNA splicing	biological process
			U12-dependent spliceosome	cellular component
			zinc ion binding	molecular function
	1.10233	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Uniprot/SWISSPROT;Acc:Q99501]	cell cycle arrest	biological process
			cytoplasm	cellular component
			cytoskeleton
	1.10831	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]	collagen binding	molecular function
			multicellular organismal development	biological process
	1.10867	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	adenohypophysis development
			cell-cell signaling
			elevation of cytosolic calcium ion concentration
			extracellular region	cellular component
			G-protein signaling, adenylate cyclase activating pathway	biological process
			growth hormone secretion
			growth hormone-releasing hormone activity	molecular function
			growth hormone-releasing hormone receptor binding
			hormone activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.