MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1019 to 1068 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
3.83977	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	molecular function	transcription factor activity
3.99682	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]	biological process	cell adhesion
			protein amino acid phosphorylation
		cellular component	membrane
		molecular function	ATP binding
			GPI anchor binding
			interleukin-1 receptor activity
			protein binding
			vascular endothelial growth factor receptor activity
4.14557	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	biological process	protein amino acid phosphorylation
		cellular component	nucleus
		molecular function	ATP binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			transferase activity
4.21401	Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	cellular component	membrane
4.40797	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	biological process	alcohol metabolic process
			carbohydrate metabolic process
			metabolic process
			neuropeptide signaling pathway
		cellular component	mitochondrion
		molecular function	aldehyde dehydrogenase (NAD) activity
			aldehyde dehydrogenase [NAD(P)+] activity
			electron carrier activity
			neuropeptide hormone activity
			oxidoreductase activity
4.4149	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	biological process	immune response
			regulation of transcription
			regulation of transcription, DNA-dependent
			transcription
		cellular component	nucleus
		molecular function	DNA binding
			protein dimerization activity
			sequence-specific DNA binding
			transcription factor activity
4.49282	Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	biological process	chromatin modification
			negative regulation of gene expression, epigenetic
			negative regulation of transcription from RNA polymerase II promoter
			positive regulation of transcription from RNA polymerase II promoter
			regulation of cell growth
			regulation of transcription, DNA-dependent
			transcription
		cellular component	nuclear membrane
			nucleoplasm
			nucleus
		molecular function	transcriptional activator activity
			transcriptional repressor activity
4.49844	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	cellular component	extracellular space
		molecular function	hormone activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.