MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene Ontology	Regulation	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 101 to 150 of 1501 in total

Regulation  : up

description	Ratio	Gene Ontology	Class
Beta-mannosidase precursor (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase). [Uniprot/SWISSPROT;Acc:O00462]	1.33329	lysosome	cellular component
		metabolic process	biological process
		protein modification process
BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	1.73291	membrane	cellular component
		potassium ion transport	biological process
		protein binding	molecular function
		voltage-gated potassium channel activity
		voltage-gated potassium channel complex	cellular component
Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]	1.61673	ATP binding	molecular function
		calcium ion binding
		calmodulin binding
		cytoplasm	cellular component
		nucleotide binding	molecular function
		nucleus	cellular component
		protein amino acid phosphorylation	biological process
		protein kinase activity	molecular function
		protein serine/threonine kinase activity
		protein-tyrosine kinase activity
		transferase activity
Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]	2.87038	calcium ion binding
		calpain activity
		cysteine-type endopeptidase activity
		cytoplasm	cellular component
		intracellular
		muscle development	biological process
		nucleus	cellular component
		peptidase activity	molecular function
		protein binding
		proteolysis	biological process
		response to calcium ion
		response to drug
		sarcomere organization
		signal transducer activity	molecular function
Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	2.70687	calcium ion binding
		homoiothermy	biological process
		ice binding	molecular function
		intracellular	cellular component
		response to freezing	biological process
		ribosome	cellular component
		structural constituent of ribosome	molecular function
		translation	biological process
CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]	1.98149	anti-apoptosis
		B cell differentiation
		B cell proliferation
		CD40 receptor binding	molecular function
		cytokine activity
		extracellular space	cellular component
		immune response	biological process
		inflammatory response
		integral to membrane	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.