MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene Ontology	Regulation	Gene	Class	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 2667 in total

description	Ratio	Gene Ontology	Regulation	Class
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	1.14311	cytoplasm	down	cellular component
		insulin-like growth factor receptor binding		molecular function
		negative regulation of protein kinase activity		biological process
		protein domain specific binding		molecular function
		protein kinase C binding
		protein kinase C inhibitor activity
		protein targeting		biological process
		regulation of neuron differentiation
		regulation of signal transduction
		regulation of synaptic plasticity
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]	2.61135	DNA damage response, detection of DNA damage
		mitochondrial small ribosomal subunit		cellular component
		mitochondrion
		peptide biosynthetic process		biological process
		ribonucleoprotein complex		cellular component
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]	2.16131	intracellular
		large ribosomal subunit
		mitochondrion
		ribosome
		structural constituent of ribosome		molecular function
		translation		biological process
40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]	2.45383	cytosolic small ribosomal subunit (sensu Eukaryota)		cellular component
		intracellular
		ribosome
		RNA binding		molecular function
		small ribosomal subunit		cellular component
		structural constituent of ribosome		molecular function
		translation		biological process
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	1.76994	cell adhesion
		integral to membrane		cellular component
		metal ion binding		molecular function
		metalloendopeptidase activity
		metallopeptidase activity
		myoblast fusion		biological process
		plasma membrane		cellular component
		protein binding		molecular function
		proteolysis		biological process
		zinc ion binding		molecular function
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	cell adhesion	up	biological process
		central nervous system development
		integral to membrane		cellular component
		integrin binding		molecular function
		membrane		cellular component
		metalloendopeptidase activity		molecular function
		negative regulation of cell adhesion		biological process
		protein binding		molecular function
		proteolysis		biological process
		zinc ion binding		molecular function
ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	1.28805	extracellular matrix	down	cellular component
		metal ion binding		molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.