MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 551 to 600 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.49923	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	biological process	small GTPase mediated signal transduction
			transmembrane receptor protein tyrosine kinase signaling pathway
		cellular component	intracellular
		molecular function	guanyl-nucleotide exchange factor activity
			protein binding
1.50284	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	biological process	intracellular protein transport
			protein complex assembly
			transport
			vesicle-mediated transport
		cellular component	cytoplasmic vesicle
			Golgi apparatus
			membrane
			membrane coat
		molecular function	protein binding
			protein transporter activity
1.50715	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Uniprot/SWISSPROT;Acc:Q969U6]	biological process	ubiquitin cycle
		molecular function	protein binding
1.51342	Beta-defensin 2 precursor (BD-2) (hBD-2) (Defensin, beta 2) (Skin- antimicrobial peptide 1) (SAP1). [Uniprot/SWISSPROT;Acc:O15263]	biological process	chemotaxis
			defense response
			defense response to bacterium
			G-protein coupled receptor protein signaling pathway
			immune response
		cellular component	extracellular region
1.5415	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Uniprot/SWISSPROT;Acc:Q86SQ0]	biological process	chloride transport
			intracellular signaling cascade
			signal transduction
		cellular component	cytoplasm
			membrane
		molecular function	phospholipase C activity
			voltage-gated chloride channel activity
1.54676	WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]	biological process	cell adhesion
		cellular component	actin cytoskeleton
			extracellular region
		molecular function	actin binding
			hormone activity
			structural molecule activity
1.55809	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Uniprot/SWISSPROT;Acc:Q14442]	biological process	GPI anchor biosynthetic process
			protein modification process
		cellular component	cytoplasm
			endoplasmic reticulum
		molecular function	phosphatidylinositol N-acetylglucosaminyltransferase activity
			transferase activity, transferring glycosyl groups
1.58045	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]	biological process	peroxisome organization and biogenesis
		cellular component	integral to peroxisomal membrane
			integral to plasma membrane
			membrane
			peroxisomal membrane
			peroxisome
		molecular function	protein binding
1.59763	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	biological process	protein modification process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.