MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.43351	down	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]	molecular function	carboxypeptidase activity
				metal ion binding
				metallopeptidase activity
				zinc ion binding
1.44004		Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]	biological process	signal transduction
			cellular component	extracellular space
				soluble fraction
			molecular function	receptor binding
1.44789	up	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Uniprot/SWISSPROT;Acc:Q16633]	biological process	humoral immune response
				regulation of transcription, DNA-dependent
				transcription
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	DNA binding
				protein binding
				transcription coactivator activity
1.45148		Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]	biological process	Golgi organization and biogenesis
				regulation of transcription, DNA-dependent
				vesicle-mediated transport
			cellular component	ER-Golgi intermediate compartment
				Golgi apparatus
				Golgi membrane
				Golgi stack
				integral to membrane
				membrane
				nucleus
			molecular function	DNA binding
				protein binding
1.45314		NULL		DNA binding
1.45624		Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]	biological process	circulation
				hemostasis
				multicellular organismal development
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
			cellular component	nucleus
			molecular function	DNA binding
				protein dimerization activity
				sequence-specific DNA binding
				transcription coactivator activity
				transcription factor activity
1.45635		Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]	biological process	cell cycle
				cell division
				mitosis
				mitotic G2 checkpoint
				positive regulation of transcription
				regulation of cyclin-dependent protein kinase activity
				regulation of progression through cell cycle
			cellular component	cytoplasm
				female pronucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.