MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 968 to 1017 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
1.37801	up	metabolic process	Glycerophosphodiester phosphodiesterase domain-containing protein 2 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 3) (Osteoblast differentiation promoting factor). [Uniprot/SWISSPROT;Acc:Q9HCC8]	biological process
1.39878		ATP binding	ATPase family AAA domain-containing protein 2B. [Uniprot/SWISSPROT;Acc:Q9ULI0]	molecular function
		nucleoside-triphosphatase activity
		nucleotide binding
1.40093		protein binding	NULL
1.40451	down	integral to membrane	COX16-like protein C14orf112, mitochondrial precursor. [Uniprot/SWISSPROT;Acc:Q9P0S2]	cellular component
		membrane
		mitochondrion
1.40552		amino acid metabolic process	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	biological process
		amino acid transport
		amino acid transporter activity		molecular function
		dicarboxylic acid transport		biological process
		integral to plasma membrane		cellular component
		membrane
		neurotransmitter transport		biological process
		neurotransmitter:sodium symporter activity		molecular function
		sodium:dicarboxylate symporter activity
		symporter activity
1.40602	up	cytoplasm	GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]	cellular component
		endoplasmic reticulum
		ER to Golgi vesicle-mediated transport		biological process
		Golgi apparatus		cellular component
		GTP binding		molecular function
		GTPase activity
		intracellular		cellular component
		intracellular protein transport		biological process
		nucleotide binding		molecular function
		small GTPase mediated signal transduction		biological process
1.40749		cell adhesion	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]
		collagen		cellular component
		cytoplasm
		dopamine receptor activity		molecular function
		extracellular matrix structural constituent
		G-protein coupled receptor protein signaling pathway		biological process
		integral to membrane		cellular component
		phosphate transport		biological process
		structural constituent of cell wall		molecular function
		structural molecule activity
1.41851	down	insulin receptor binding	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]
		MAPKKK cascade		biological process
		nervous system development
		transmembrane receptor protein tyrosine kinase signaling pathway
		transmembrane receptor protein tyrosine kinase signaling protein activity		molecular function
1.42215		integral to plasma membrane	Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	cellular component
		membrane
		monoamine transport		biological process
		monoamine transporter activity		molecular function
		neurotransmitter transport		biological process
		neurotransmitter uptake
		neurotransmitter:sodium symporter activity		molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.