MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 900 to 949 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.35022	up	N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	cellular component	intracellular
				mitochondrion
				nucleoplasm
				nucleus
			molecular function	damaged DNA binding
				DNA binding
				endonuclease activity
				hydrolase activity, acting on glycosyl bonds
				lyase activity
				microtubule binding
				oxidized purine base lesion DNA N-glycosylase activity
				protein binding
1.351	down	TBK1 binding protein 1 [RefSeq_peptide;Acc:NP_055541]	biological process	G-protein coupled receptor protein signaling pathway
			cellular component	integral to membrane
			molecular function	dopamine receptor activity
1.35125	up	Geminin. [Uniprot/SWISSPROT;Acc:O75496]	biological process	cell cycle
				negative regulation of DNA replication
				negative regulation of progression through cell cycle
				organ morphogenesis
				regulation of progression through cell cycle
			cellular component	nucleus
			molecular function	protein binding
1.36349	down	Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]	biological process	regulation of progression through cell cycle
				spermatogenesis
1.36755		Nucleolar preribosomal-associated protein 1 (Fragment). [Uniprot/SWISSPROT;Acc:O60287]		biological_process
			cellular component	nucleolus
				nucleus
			molecular function	molecular_function
1.36911		Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65]	biological process	G-protein coupled receptor protein signaling pathway
				signal transduction
			cellular component	integral to membrane
				membrane
			molecular function	bombesin receptor activity
				metabotropic glutamate, GABA-B-like receptor activity
				neuropeptide receptor activity
				neuropeptide Y receptor activity
				orexin receptor activity
				purinergic nucleotide receptor activity, G-protein coupled
				receptor activity
				rhodopsin-like receptor activity
1.36997	up	Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Uniprot/SWISSPROT;Acc:Q8N264]	biological process	angiogenesis
				cell differentiation
				multicellular organismal development
				signal transduction
			cellular component	cell junction
				cytoplasm
				cytoskeleton
				intracellular
				membrane
			molecular function	GTPase activator activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.