MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 701 to 750 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.76583	leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	molecular function	aminopeptidase activity
			membrane alanyl aminopeptidase activity
			metallopeptidase activity
			N-terminal arginine aminopeptidase activity
			N-terminal lysine aminopeptidase activity
			zinc ion binding
1.76994	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	biological process	cell adhesion
			myoblast fusion
			proteolysis
		cellular component	integral to membrane
			plasma membrane
		molecular function	metal ion binding
			metalloendopeptidase activity
			metallopeptidase activity
			protein binding
			zinc ion binding
1.80858	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	biological process	signal transduction
		cellular component	intracellular
		molecular function	protein binding
			small GTPase regulator activity
1.80942	Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	cellular component	integral to membrane
			membrane
1.81557	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	biological process	homoiothermy
			response to freezing
		cellular component	nucleus
		molecular function	ATP binding
			DNA binding
			helicase activity
			hydrolase activity
			ice binding
			nucleic acid binding
			nucleotide binding
1.82063	Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	cellular component	integral to membrane
			membrane
1.82311	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	biological process	cell proliferation
			cell-cell signaling
			fibroblast growth factor receptor signaling pathway
			glial cell differentiation
			nervous system development
			regulation of progression through cell cycle
		cellular component	extracellular space
		molecular function	growth factor activity
1.86204	Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]	biological process	regulation of transcription, DNA-dependent
			transcription
		cellular component	intracellular
			nucleus
		molecular function	metal ion binding
			nucleic acid binding
			transcription factor activity
			zinc ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.