MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	description	Class	Accession	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 651 to 700 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.28356	ice binding	down	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]	molecular function
	mammary gland development			biological process
	membrane			cellular component
	multicellular organismal development			biological process
	muscle cell fate determination
	negative regulation of transcription from RNA polymerase II promoter
	nucleoside transporter activity			molecular function
	nucleus			cellular component
	positive regulation of cell proliferation			biological process
	protein binding			molecular function
	regulation of transcription, DNA-dependent			biological process
	response to freezing
	sequence-specific DNA binding			molecular function
	transcription			biological process
	transcription factor activity			molecular function
	transcription factor complex			cellular component
	transcriptional repressor activity			molecular function
	transport			biological process
1.28514	calcium ion binding	up	EF-hand domain-containing protein C17orf57. [Uniprot/SWISSPROT;Acc:Q8IY85]	molecular function
1.28698	mRNA processing		THO complex subunit 2 (Tho2). [Uniprot/SWISSPROT;Acc:Q8NI27]	biological process
	mRNA transport
	nucleus			cellular component
	RNA binding			molecular function
	RNA splicing			biological process
	transport
1.28805	extracellular matrix	down	ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	cellular component
	metal ion binding			molecular function
	metalloendopeptidase activity
	metallopeptidase activity
	peptidase activity
	proteinaceous extracellular matrix			cellular component
	proteolysis			biological process
	zinc ion binding			molecular function
1.29151	binding	up	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]
	cell cycle			biological process
	cell division
	cytoplasm			cellular component
	cytoplasmic microtubule
	cytoskeleton
	establishment and/or maintenance of cell polarity			biological process
	galactoside 2-alpha-L-fucosyltransferase activity			molecular function
	Golgi apparatus			cellular component
	kinetochore microtubule
	microtubule binding			molecular function
	microtubule plus-end binding
	mitosis			biological process
	negative regulation of microtubule depolymerization
	protein binding			molecular function
	regulation of microtubule polymerization or depolymerization			biological process
1.29238	FAD binding		Coiled-coil and C2 domain-containing protein 1B. [Uniprot/SWISSPROT;Acc:Q5T0F9]	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.