MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	Ratio	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 651 to 700 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.683	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	molecular function	ribonuclease activity
			RNA binding
1.69153	Keratin-associated protein 19-2. [Uniprot/SWISSPROT;Acc:Q3LHN2]	cellular component	intermediate filament
1.693	CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]	biological process	metabolic process
		molecular function	catalytic activity
			iron-sulfur cluster binding
1.69658	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]	biological process	protein amino acid glycosylation
		cellular component	Golgi apparatus
			integral to Golgi membrane
			integral to membrane
			membrane
		molecular function	beta-galactoside alpha-2,3-sialyltransferase activity
			sialyltransferase activity
			transferase activity, transferring glycosyl groups
1.72628	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]	biological process	DNA repair
		cellular component	integral to membrane
			membrane
		molecular function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
			structural molecule activity
1.72656	protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	biological process	ER overload response
			response to hydrogen peroxide
			response to oxidative stress
		cellular component	protein phosphatase type 1 complex
		molecular function	protein serine/threonine phosphatase activity
1.73211	Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	biological process	cell cycle
			cell proliferation
			meiosis
			regulation of progression through cell cycle
		cellular component	chromosome, pericentric region
			condensed chromosome
			cytoplasm
			nucleolus
			nucleus
		molecular function	ATP binding
			nucleotide binding
			protein binding
1.74736	Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]	cellular component	cytoplasm
			membrane
1.75846	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	biological process	amino acid metabolic process
			L-cystine transport
			transport
		cellular component	integral to membrane
			lysosomal membrane
			lysosome
			membrane
		molecular function	L-cystine transporter activity
1.76583	leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	biological process	antigen processing and presentation of endogenous peptide antigen via MHC class I
			blood pressure regulation
			proteolysis
		cellular component	endoplasmic reticulum lumen

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.