MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 640 to 689 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.28319	up	Autophagy-related protein 10 (APG10-like). [Uniprot/SWISSPROT;Acc:Q9H0Y0]	biological process	positive regulation of protein modification
				protein amino acid lipidation
				protein transport
				ubiquitin cycle
			cellular component	cytoplasm
				intracellular
			molecular function	protein binding
1.28356	down	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]	biological process	cardiac muscle development
				cell aging
				heart morphogenesis
				homoiothermy
				mammary gland development
				multicellular organismal development
				muscle cell fate determination
				negative regulation of transcription from RNA polymerase II promoter
				positive regulation of cell proliferation
				regulation of transcription, DNA-dependent
				response to freezing
				transcription
				transport
			cellular component	membrane
				nucleus
				transcription factor complex
			molecular function	ice binding
				nucleoside transporter activity
				protein binding
				sequence-specific DNA binding
				transcription factor activity
				transcriptional repressor activity
1.28514	up	EF-hand domain-containing protein C17orf57. [Uniprot/SWISSPROT;Acc:Q8IY85]		calcium ion binding
1.28698		THO complex subunit 2 (Tho2). [Uniprot/SWISSPROT;Acc:Q8NI27]	biological process	mRNA processing
				mRNA transport
				RNA splicing
				transport
			cellular component	nucleus
			molecular function	RNA binding
1.28805	down	ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	biological process	proteolysis
			cellular component	extracellular matrix
				proteinaceous extracellular matrix
			molecular function	metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				peptidase activity
				zinc ion binding
1.29151	up	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]	biological process	cell cycle
				cell division
				establishment and/or maintenance of cell polarity
				mitosis
				negative regulation of microtubule depolymerization
				regulation of microtubule polymerization or depolymerization

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.