MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 605 to 654 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.2734	up	Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	integral to membrane	cellular component
			membrane
			neurotransmitter secretion	biological process
			protein binding	molecular function
			synaptic transmission	biological process
			synaptogenesis
1.27461	down	Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	anatomical structure morphogenesis
			DNA binding	molecular function
			G-protein coupled receptor protein signaling pathway	biological process
			galanin receptor activity	molecular function
			integral to membrane	cellular component
			multicellular organismal development	biological process
			nucleus	cellular component
			regulation of transcription, DNA-dependent	biological process
			sequence-specific DNA binding	molecular function
			thyroid gland development	biological process
			transcription factor activity	molecular function
1.27516	up	Uncharacterized protein C16orf48. [Uniprot/SWISSPROT;Acc:Q9H0I2]	microtubule cytoskeleton	cellular component
1.27696	down	Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	cell cycle	biological process
			G1/S transition of mitotic cell cycle
			multicellular organismal development
			nucleus	cellular component
			positive regulation of cell proliferation	biological process
			positive regulation of cyclin-dependent protein kinase activity
			protein amino acid dephosphorylation
			protein binding	molecular function
			protein kinase binding
			protein phosphatase type 1 activity
			regulation of progression through cell cycle	biological process
			response to DNA damage stimulus
1.27802		Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]	homoiothermy
			ice binding	molecular function
			protein binding
			response to freezing	biological process
1.28319	up	Autophagy-related protein 10 (APG10-like). [Uniprot/SWISSPROT;Acc:Q9H0Y0]	autophagy
			cytoplasm	cellular component
			intracellular
			positive regulation of protein modification	biological process
			protein amino acid lipidation
			protein binding	molecular function
			protein transport	biological process
			ubiquitin cycle
1.28356	down	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]	cardiac muscle development
			cell aging
			heart morphogenesis
			homoiothermy
			ice binding	molecular function
			mammary gland development	biological process
			membrane	cellular component
			multicellular organismal development	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.