Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Gene Ontology Accession Regulation Ratio Gene description Class Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 569 to 618 of 2667 in total
Gene Ontology
Regulation
Ratio
description
Class
epithelial to mesenchymal transition down 1.49558 Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643] biological process
ER overload response 1.72656 protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]
ER to Golgi vesicle-mediated transport up 1.40602 GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]
2.48474 BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). [Uniprot/SWISSPROT;Acc:O15155]
ER-Golgi intermediate compartment down 1.24361 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908] cellular component
up 1.45148 Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]
erythrocyte differentiation 1.19545 Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115] biological process
establishment and/or maintenance of cell polarity 1.29151 CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]
establishment and/or maintenance of chromatin architecture 4.55177 Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]
establishment of mitotic spindle localization down 1.2984 nucleolar and spindle associated protein 1 isoform 2 [RefSeq_peptide;Acc:NP_060924]
establishment of synaptic specificity at neuromuscular junction up 1.61987 Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]
eukaryotic translation elongation factor 1 complex 3.21473 Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma). [Uniprot/SWISSPROT;Acc:P26641] cellular component
excretion 1.31661 Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879] biological process
exocytosis down 1.24359 Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]
exonuclease activity 1.683 Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1] molecular function
exosome (RNase complex) cellular component
external side of plasma membrane up 1.25147 T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]
extracellular matrix down 1.28805 ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]
3.66058 olfactomedin-like 2A [RefSeq_peptide;Acc:NP_872293]
up 2.45875 ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]
extracellular matrix binding down 3.66058 olfactomedin-like 2A [RefSeq_peptide;Acc:NP_872293] molecular function
extracellular matrix structural constituent up 1.40749 collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]
extracellular region down 1.13541 Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435] cellular component
1.1611 Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]
1.19212 Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]
1.49558 Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]
1.51342 Beta-defensin 2 precursor (BD-2) (hBD-2) (Defensin, beta 2) (Skin- antimicrobial peptide 1) (SAP1). [Uniprot/SWISSPROT;Acc:O15263]
1.54676 WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]
2.08208 Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]
3.05037 Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]
3.11758 Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]
up 1.10867 Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]
1.19545 Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]
2.65068 NULL
2.7017 Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]
extracellular space down 1.44004 Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]
1.49558 Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]
1.82311 Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]
3.11758 Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]
4.49844 Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]
up 1.86433 CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]
1.98149 CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
FAD binding 1.20102 Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3] molecular function
1.29238 Coiled-coil and C2 domain-containing protein 1B. [Uniprot/SWISSPROT;Acc:Q5T0F9]
fatty acid biosynthetic process down 1.18096 Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354] biological process
fatty acid oxidation up 5.19755 Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]
female genitalia development 1.25808 Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]
female pronucleus 1.45635 Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248] cellular component
ferric-chelate reductase activity 1.20102 Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3] molecular function
fibroblast growth factor receptor activity down 1.30142 Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/