Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation Gene Ontology description Accession Class Gene Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 551 to 600 of 2667 in total
Ratio	Regulation	Gene Ontology	description	Class	
1.25147	up	positive regulation of interleukin-4 biosynthetic process	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Source:Uniprot/SWISSPROT;Acc:P42081]	biological process	
1.25147	up	positive regulation of lymphotoxin A biosynthetic process	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Source:Uniprot/SWISSPROT;Acc:P42081]	biological process	
1.25147	up	positive regulation of T-helper 2 cell differentiation	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Source:Uniprot/SWISSPROT;Acc:P42081]	biological process	
1.25147	up	positive regulation of transcription	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Source:Uniprot/SWISSPROT;Acc:P42081]	biological process	
1.25147	up	protein binding	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Source:Uniprot/SWISSPROT;Acc:P42081]	molecular function	
1.25147	up	T cell activation	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Source:Uniprot/SWISSPROT;Acc:P42081]	biological process	
1.25147	up	T cell proliferation	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Source:Uniprot/SWISSPROT;Acc:P42081]	biological process	
1.25147	up	transcriptional activator activity	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Source:Uniprot/SWISSPROT;Acc:P42081]	molecular function	
1.25205	down	7S RNA binding	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	molecular function	
1.25205	down	GTP binding	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	molecular function	
1.25205	down	membrane	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	cellular component	
1.25205	down	nuclear mRNA splicing, via spliceosome	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	biological process	
1.25205	down	nucleus	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	cellular component	
1.25205	down	RNA binding	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	molecular function	
1.25205	down	RNA splicing	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	biological process	
1.25205	down	spliceosome	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	cellular component	
1.25205	down	SRP-dependent cotranslational protein targeting to membrane	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	biological process	
1.25729	up	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Source:Uniprot/SWISSPROT;Acc:Q96LJ7]	molecular function	
1.25729	up	endoplasmic reticulum	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Source:Uniprot/SWISSPROT;Acc:Q96LJ7]	cellular component	
1.25729	up	enterobactin biosynthetic process	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Source:Uniprot/SWISSPROT;Acc:Q96LJ7]	biological process	
1.25729	up	metabolic process	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Source:Uniprot/SWISSPROT;Acc:Q96LJ7]	biological process	
1.25729	up	mitochondrial inner membrane	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Source:Uniprot/SWISSPROT;Acc:Q96LJ7]	cellular component	
1.25729	up	oxidoreductase activity	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Source:Uniprot/SWISSPROT;Acc:Q96LJ7]	molecular function	
1.25808	up	adult heart development	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	adult walking behavior	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	ATP binding	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	molecular function	
1.25808	up	blood vessel development	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	camera-type eye development	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	chromatin	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	cellular component	
1.25808	up	chromatin assembly or disassembly	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	chromatin binding	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	molecular function	
1.25808	up	chromatin modification	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	circulation	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	DNA binding	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	molecular function	
1.25808	up	embryonic hindlimb morphogenesis	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	female genitalia development	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	heart morphogenesis	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	helicase activity	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	molecular function	
1.25808	up	hydrolase activity	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	molecular function	
1.25808	up	in utero embryonic development	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	inner ear morphogenesis	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	locomotory behavior	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	nose development	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	nucleic acid binding	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	molecular function	
1.25808	up	nucleotide binding	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	molecular function	
1.25808	up	nucleus	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	cellular component	
1.25808	up	palate development	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	positive regulation of body size	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	regulation of transcription, DNA-dependent	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	
1.25808	up	sensory perception of sound	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.
- http://analysis.yellowcouch.org/