MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 468 to 517 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	transcription from RNA polymerase II promoter	biological process
			zinc ion binding	molecular function
1.22694		Protein FAM73B. [Uniprot/SPTREMBL;Acc:Q7L4E1]	type I hypersensitivity	biological process
1.23668	down	Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	actin binding	molecular function
			ATP binding
			biological_process	biological process
			calmodulin binding	molecular function
			motor activity
			myosin complex	cellular component
			nucleoside-triphosphatase activity	molecular function
			nucleotide binding
			unconventional myosin complex	cellular component
1.23783		Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]	cytoplasm
			GTPase activator activity	molecular function
			intracellular	cellular component
			metal ion binding	molecular function
			phosphatidylinositol-3,4,5-triphosphate binding
			regulation of GTPase activity	biological process
			signal transduction
			zinc ion binding	molecular function
1.23845		Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	cell proliferation	biological process
			cholesterol metabolic process
			endoplasmic reticulum	cellular component
			integral to membrane
			lipid metabolic process	biological process
			membrane	cellular component
			metabolic process	biological process
			protein binding	molecular function
			response to sterol depletion	biological process
			steroid metabolic process
1.24114		Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	actin binding	molecular function
			ATP binding
			calmodulin binding
			intracellular	cellular component
			motor activity	molecular function
			myosin complex	cellular component
			nucleotide binding	molecular function
			signal transduction	biological process
			striated muscle contraction
			striated muscle thick filament	cellular component
1.24359		Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]	calcium ion binding	molecular function
			cell junction	cellular component
			cytoplasmic vesicle
			exocytosis	biological process
			lipid binding	molecular function
			membrane	cellular component
			protein transport	biological process
			synapse	cellular component
1.24361		Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	calcium ion binding	molecular function
			endoplasmic reticulum	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.