Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio Regulation Gene Ontology description Accession Class Gene Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 451 to 500 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class	
1.22502	up	transporter activity	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Source:Uniprot/SWISSPROT;Acc:Q99758]	molecular function	
1.22528	up	dephosphorylation	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	biological process	
1.22528	up	hydrolase activity	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	molecular function	
1.22528	up	phosphoric monoester hydrolase activity	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	molecular function	
1.22528	up	protein amino acid dephosphorylation	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	biological process	
1.22528	up	protein tyrosine phosphatase activity	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	molecular function	
1.22528	up	protein tyrosine/serine/threonine phosphatase activity	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	molecular function	
1.22576	up	DNA binding	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	molecular function	
1.22576	up	metal ion binding	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	molecular function	
1.22576	up	methyl-CpG binding	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	molecular function	
1.22576	up	negative regulation of transcription	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	biological process	
1.22576	up	nucleus	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	cellular component	
1.22576	up	protein binding	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	molecular function	
1.22576	up	regulation of transcription, DNA-dependent	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	biological process	
1.22576	up	transcription	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	biological process	
1.22576	up	transcription corepressor activity	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	molecular function	
1.22576	up	transcription factor activity	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	molecular function	
1.22576	up	transcription from RNA polymerase II promoter	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	biological process	
1.22576	up	zinc ion binding	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	molecular function	
1.22694	up	type I hypersensitivity	Protein FAM73B. [Source:Uniprot/SPTREMBL;Acc:Q7L4E1]	biological process	
1.23668	down	actin binding	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	molecular function	
1.23668	down	ATP binding	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	molecular function	
1.23668	down	biological_process	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	biological process	
1.23668	down	calmodulin binding	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	molecular function	
1.23668	down	motor activity	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	molecular function	
1.23668	down	myosin complex	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	cellular component	
1.23668	down	nucleoside-triphosphatase activity	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	molecular function	
1.23668	down	nucleotide binding	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	molecular function	
1.23668	down	unconventional myosin complex	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	cellular component	
1.23783	down	cytoplasm	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	cellular component	
1.23783	down	GTPase activator activity	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	molecular function	
1.23783	down	intracellular	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	cellular component	
1.23783	down	metal ion binding	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	molecular function	
1.23783	down	phosphatidylinositol-3,4,5-triphosphate binding	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	molecular function	
1.23783	down	regulation of GTPase activity	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	biological process	
1.23783	down	signal transduction	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	biological process	
1.23783	down	zinc ion binding	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	molecular function	
1.23845	down	cell proliferation	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	biological process	
1.23845	down	cholesterol metabolic process	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	biological process	
1.23845	down	endoplasmic reticulum	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	cellular component	
1.23845	down	integral to membrane	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	cellular component	
1.23845	down	lipid metabolic process	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	biological process	
1.23845	down	membrane	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	cellular component	
1.23845	down	metabolic process	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	biological process	
1.23845	down	protein binding	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	molecular function	
1.23845	down	response to sterol depletion	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	biological process	
1.23845	down	steroid metabolic process	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	biological process	
1.24114	down	actin binding	Myosin-15 (Myosin heavy chain 15). [Source:Uniprot/SWISSPROT;Acc:Q9Y2K3]	molecular function	
1.24114	down	ATP binding	Myosin-15 (Myosin heavy chain 15). [Source:Uniprot/SWISSPROT;Acc:Q9Y2K3]	molecular function	
1.24114	down	calmodulin binding	Myosin-15 (Myosin heavy chain 15). [Source:Uniprot/SWISSPROT;Acc:Q9Y2K3]	molecular function	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/