MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	description	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 451 to 500 of 2667 in total

Ratio	description	Regulation	Class	Gene Ontology
1.22502	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	up	molecular function	transporter activity
1.22528	protein tyrosine phosphatase domain containing 1 protein isoform 2 [RefSeq_peptide;Acc:NP_818931]		biological process	dephosphorylation
				protein amino acid dephosphorylation
			molecular function	hydrolase activity
				phosphoric monoester hydrolase activity
				protein tyrosine phosphatase activity
				protein tyrosine/serine/threonine phosphatase activity
1.22576	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]		biological process	negative regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	DNA binding
				metal ion binding
				methyl-CpG binding
				protein binding
				transcription corepressor activity
				transcription factor activity
				zinc ion binding
1.22694	Protein FAM73B. [Uniprot/SPTREMBL;Acc:Q7L4E1]		biological process	type I hypersensitivity
1.23668	Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	down		biological_process
			cellular component	myosin complex
				unconventional myosin complex
			molecular function	actin binding
				ATP binding
				calmodulin binding
				motor activity
				nucleoside-triphosphatase activity
				nucleotide binding
1.23783	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]		biological process	regulation of GTPase activity
				signal transduction
			cellular component	cytoplasm
				intracellular
			molecular function	GTPase activator activity
				metal ion binding
				phosphatidylinositol-3,4,5-triphosphate binding
				zinc ion binding
1.23845	Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]		biological process	cell proliferation
				cholesterol metabolic process
				lipid metabolic process
				metabolic process
				response to sterol depletion
				steroid metabolic process
			cellular component	endoplasmic reticulum
				integral to membrane
				membrane
			molecular function	protein binding
1.24114	Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]		biological process	signal transduction
				striated muscle contraction
			cellular component	intracellular

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.