MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 451 to 500 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.41851	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]	transmembrane receptor protein tyrosine kinase signaling protein activity	molecular function
1.42215	Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	integral to plasma membrane	cellular component
		membrane
		monoamine transport	biological process
		monoamine transporter activity	molecular function
		neurotransmitter transport	biological process
		neurotransmitter uptake
		neurotransmitter:sodium symporter activity	molecular function
		protein binding
		serotonin transport	biological process
		serotonin transporter activity	molecular function
		serotonin:sodium symporter activity
		symporter activity
1.43088	Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	carotenoid biosynthetic process	biological process
		cholesterol biosynthetic process
		hydrolase activity	molecular function
		isomerase activity
		isopentenyl-diphosphate delta-isomerase activity
		isoprenoid biosynthetic process	biological process
		magnesium ion binding	molecular function
		peroxisome	cellular component
1.43351	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]	carboxypeptidase A activity	molecular function
		carboxypeptidase activity
		metal ion binding
		metallopeptidase activity
		proteolysis	biological process
		vacuolar protein catabolic process
		zinc ion binding	molecular function
1.44004	Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]	extracellular space	cellular component
		receptor binding	molecular function
		signal transduction	biological process
		soluble fraction	cellular component
1.48363	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291]	ATP binding	molecular function
		cell cycle	biological process
		cell division
		magnesium ion binding	molecular function
		mitosis	biological process
		nucleotide binding	molecular function
		nucleus	cellular component
		protein amino acid phosphorylation	biological process
		protein binding	molecular function
		protein kinase activity
		protein serine/threonine kinase activity
		protein-tyrosine kinase activity
		regulation of progression through cell cycle	biological process
		transferase activity	molecular function
1.48389	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]	ATP binding
		ATP synthesis coupled proton transport	biological process
		DNA binding	molecular function
		hydrogen ion transporting ATP synthase activity, rotational mechanism

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.