MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Accession	Regulation	Ratio	Gene Ontology	Minimum Ratio	description	Class	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2551 to 2600 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
4.07995	transport	AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]	biological process
	transport vesicle		cellular component
	transporter activity		molecular function
	vesicle-mediated transport		biological process
4.1026	cell proliferation	Uncharacterized protein C2orf29. [Uniprot/SWISSPROT;Acc:Q9UKZ1]
	cellular_component		cellular component
	molecular_function		molecular function
4.14054	embryonic skeletal morphogenesis	Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]	biological process
	intracellular		cellular component
	metal ion binding		molecular function
	nucleic acid binding
	nucleus		cellular component
	positive regulation of cell proliferation		biological process
	zinc ion binding		molecular function
4.22898	catalytic activity	Enoyl-CoA hydratase domain-containing protein 1. [Uniprot/SWISSPROT;Acc:Q9NTX5]
	metabolic process		biological process
4.40598	catalytic activity	GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]	molecular function
	GMP reductase activity
	metabolic process		biological process
	metal ion binding		molecular function
	nucleotide metabolic process		biological process
	oxidoreductase activity		molecular function
	potassium ion binding
	response to cold		biological process
4.55177	chromatin	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	cellular component
	DNA binding		molecular function
	establishment and/or maintenance of chromatin architecture		biological process
	nervous system development
	nucleus		cellular component
	regulation of transcription, DNA-dependent		biological process
	transcription
	transcription factor activity		molecular function
4.55371	cytoplasm	Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	cellular component
	G-protein coupled receptor activity		molecular function
	G-protein signaling, coupled to cyclic nucleotide second messenger		biological process
	integral to membrane		cellular component
	integral to plasma membrane
	membrane
	nucleus
	parathyroid hormone receptor activity		molecular function
	receptor activity
	signal transduction		biological process
	skeletal development
4.67988	delayed rectifier potassium channel activity	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	molecular function
	dicarboxylic acid transport		biological process
	integral to membrane		cellular component
	ion channel activity		molecular function
	ion transport		biological process
	membrane		cellular component
	membrane fraction

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.