MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Accession	Gene	Class	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 251 to 300 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.19117	up	Ras-related GTP-binding protein D (Rag D). [Uniprot/SWISSPROT;Acc:Q9NQL2]	signal transducer activity	molecular function
			transport	biological process
1.19134	down	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	calcium ion binding	molecular function
			cell-cell signaling	biological process
			determination of left/right symmetry
			endoplasmic reticulum	cellular component
			intracellular
			membrane
			nucleic acid binding	molecular function
			peptidase activity
			proteolysis	biological process
			subtilase activity	molecular function
			zinc ion binding
			zygotic determination of anterior/posterior axis, embryo	biological process
1.19207	up	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Uniprot/SWISSPROT;Acc:Q9GZY0]	cytoplasm	cellular component
			intracellular
			mRNA export from nucleus	biological process
			multicellular organismal development
			nuclear RNA export factor complex	cellular component
			nucleotide binding	molecular function
			nucleus	cellular component
			protein binding	molecular function
			RNA binding
			transport	biological process
1.19212	down	Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]	extracellular region	cellular component
			hormone activity	molecular function
			hormone biosynthetic process	biological process
			signal transduction
			thyroid hormone generation
1.19496	up	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]	carbohydrate metabolic process
			cytoplasm	cellular component
			cytosol
			glutathione metabolic process	biological process
			glyoxylate cycle
			isocitrate dehydrogenase (NADP+) activity	molecular function
			isocitrate metabolic process	biological process
			magnesium ion binding	molecular function
			manganese ion binding
			metabolic process	biological process
			oxidoreductase activity	molecular function
			oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
			peroxisome	cellular component
			response to oxidative stress	biological process
			tricarboxylic acid cycle
1.19539		Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]	amino acid metabolic process
			catalytic activity	molecular function
			cysteine desulfurase activity
			cytoplasm	cellular component
			cytosol
			lyase activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.