MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 26 to 75 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.10867	up	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	biological process	positive regulation of growth hormone secretion
				positive regulation of hormone secretion
				positive regulation of transcription
				signal transduction
			cellular component	extracellular region
				terminal button
			molecular function	growth hormone-releasing hormone activity
				growth hormone-releasing hormone receptor binding
				hormone activity
1.10889		Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	cytoplasm
				nucleus
			molecular function	protein dimerization activity
				sequence-specific DNA binding
				transcription factor activity
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	biological process	neurotransmitter transport
			cellular component	integral to plasma membrane
				membrane
				plasma membrane
			molecular function	neurotransmitter:sodium symporter activity
				symporter activity
				transporter activity
1.11519	up	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	biological process	translational initiation
			cellular component	cytoplasm
			molecular function	RNA binding
				translation initiation factor activity
1.11956	down	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]	biological process	retrograde vesicle-mediated transport, Golgi to ER
			cellular component	Golgi apparatus
				integral to Golgi membrane
				integral to membrane
				membrane
			molecular function	molecular_function
1.12417	up	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]	biological process	protein homooligomerization
				protein localization
				response to metal ion
			cellular component	membrane
			molecular function	enzyme binding
				protein heterodimerization activity
				retinoic acid receptor binding
				retinoid-X receptor activity
				thyroid hormone receptor binding
				thyroid hormone receptor coactivator activity
				vitamin D receptor binding
1.1243	down	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	intracellular
				nucleus
			molecular function	DNA binding
				metal ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.