MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 218 to 267 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	molecular function	prostaglandin-endoperoxide synthase activity
				protein binding
1.18141		Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein). [Uniprot/SWISSPROT;Acc:Q9HA64]		kinase activity
				transferase activity
1.18263	up	Fibroblast growth factor-binding protein 3 precursor (FGF-binding protein 3) (FGF-BP3) (FGFBP-3). [Uniprot/SWISSPROT;Acc:Q8TAT2]		growth factor binding
1.18489		Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	biological process	cGMP biosynthetic process
				cyclic nucleotide biosynthetic process
				intracellular signaling cascade
			cellular component	cytoplasm
			molecular function	guanylate cyclase activity
				heme binding
				iron ion binding
				metal ion binding
				phosphorus-oxygen lyase activity
1.18711		NULL		protein binding
1.18821	down	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	biological process	cytokine and chemokine mediated signaling pathway
				respiratory gaseous exchange
				signal transduction
			cellular component	granulocyte macrophage colony-stimulating factor receptor complex
				integral to membrane
				membrane
			molecular function	hematopoietin/interferon-class (D200-domain) cytokine receptor activity
				interleukin receptor activity
				interleukin-3 receptor activity
				interleukin-5 receptor activity
				receptor activity
1.19117	up	Ras-related GTP-binding protein D (Rag D). [Uniprot/SWISSPROT;Acc:Q9NQL2]	biological process	G-protein coupled receptor protein signaling pathway
				transport
			cellular component	cytoplasm
				nucleus
			molecular function	GTP binding
				guanyl nucleotide binding
				nucleotide binding
				protein binding
				signal transducer activity
1.19134	down	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	biological process	cell-cell signaling
				determination of left/right symmetry
				proteolysis
				zygotic determination of anterior/posterior axis, embryo
			cellular component	endoplasmic reticulum
				intracellular
				membrane
			molecular function	calcium ion binding
				nucleic acid binding
				peptidase activity
				subtilase activity
				zinc ion binding
1.19207	up	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Uniprot/SWISSPROT;Acc:Q9GZY0]	biological process	mRNA export from nucleus
				multicellular organismal development
				transport

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.