MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 2119 to 2168 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
3.15011	down	Ninein-like protein. [Uniprot/SWISSPROT;Acc:Q9Y2I6]	cellular component	cytoplasm
				microtubule
			molecular function	calcium ion binding
3.21473	up	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma). [Uniprot/SWISSPROT;Acc:P26641]	biological process	translational elongation
			cellular component	eukaryotic translation elongation factor 1 complex
				intracellular
			molecular function	protein binding
				translation elongation factor activity
3.21581		NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]	cellular component	cytoplasm
			molecular function	ATP binding
				ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
				endonuclease activity
				hydrolase activity
				nucleotide binding
				protein binding
3.26367		Probable fibrosin-1 long transcript protein. [Uniprot/SWISSPROT;Acc:Q9HAH7]	biological process	homoiothermy
				response to freezing
				type I hypersensitivity
			molecular function	ice binding
3.27919	down	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]	biological process	apoptosis
				behavior
				ion transport
				negative regulation of transcription from RNA polymerase II promoter
				potassium ion transport
				regulation of neuron apoptosis
				regulation of transcription from RNA polymerase II promoter
				response to pain
				sensory perception of pain
				signal transduction
				transcription
			cellular component	cytoplasm
				cytosol
				endoplasmic reticulum
				Golgi apparatus
				membrane
				nucleus
			molecular function	calcium ion binding
				calcium-dependent protein binding
				DNA binding
				ion channel activity
				potassium channel activity
				potassium ion binding
				protein C-terminus binding
				specific transcriptional repressor activity
				transcription corepressor activity
				voltage-gated ion channel activity
3.29064		Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	biological process	liver development
				muscle development
				positive regulation of transcription
				positive regulation of transcription from RNA polymerase II promoter

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.