MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	Accession	description	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2069 to 2118 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
2.91954	up	RNA splicing	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	biological process
2.93895	down	cytoplasm	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	cellular component
		I-kappaB kinase/NF-kappaB cascade		biological process
		metal ion binding		molecular function
		protein binding
		signal transduction		biological process
		zinc ion binding		molecular function
2.95579	up	cytoplasm	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Uniprot/SWISSPROT;Acc:Q8TE77]	cellular component
		cytoskeleton
		dephosphorylation		biological process
		hydrolase activity		molecular function
		nucleus		cellular component
		phosphoric monoester hydrolase activity		molecular function
		protein amino acid dephosphorylation		biological process
		protein tyrosine phosphatase activity		molecular function
		protein tyrosine/serine/threonine phosphatase activity
2.96739		nucleus	Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]	cellular component
		protein binding		molecular function
3.00923	down	acetyltransferase activity	Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]
		arylamine N-acetyltransferase activity
		cytoplasm		cellular component
		metabolic process		biological process
		transferase activity		molecular function
3.03423	up	binding	Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]
		kinetochore		cellular component
		mitosis		biological process
		regulation of progression through cell cycle
		ubiquitin cycle
		ubiquitin ligase complex		cellular component
3.05037	down	calcium ion binding	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	molecular function
		cell adhesion		biological process
		extracellular region		cellular component
		heparin binding		molecular function
		protein binding
		proteinaceous extracellular matrix		cellular component
		structural molecule activity		molecular function
		substrate-bound cell migration, cell extension		biological process
3.06659		ATP binding	ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]	molecular function
		nucleotide binding
3.07625		cell motility	Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	biological process
		cell proliferation
		integral to membrane		cellular component
		membrane
3.11758		cytokine activity	Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	molecular function
		extracellular region		cellular component
		extracellular space
		growth		biological process
		growth factor activity		molecular function
3.14866	up	integral to membrane	Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]	cellular component
		membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.