MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2019 to 2068 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.86298	up	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	cellular component	nucleus
			molecular function	DNA binding
				ligand-dependent nuclear receptor activity
				transcription factor activity
2.86538		Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). [Uniprot/SWISSPROT;Acc:Q8NGS2]	biological process	G-protein coupled receptor protein signaling pathway
				sensory perception of smell
			cellular component	integral to membrane
			molecular function	cannabinoid receptor activity
				olfactory receptor activity
				receptor activity
				rhodopsin-like receptor activity
2.86965		RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]	biological process	DNA topological change
			cellular component	chromosome
				nucleus
			molecular function	ATP binding
				DNA binding
				DNA topoisomerase (ATP-hydrolyzing) activity
				nucleic acid binding
				nucleotide binding
				RNA binding
2.87038		Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]	biological process	muscle development
				proteolysis
				response to calcium ion
				response to drug
				sarcomere organization
			cellular component	cytoplasm
				intracellular
				nucleus
			molecular function	calcium ion binding
				calpain activity
				cysteine-type endopeptidase activity
				peptidase activity
				protein binding
				signal transducer activity
2.88128	down	CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]	cellular component	integral to membrane
				membrane
			molecular function	sugar binding
2.88235		Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]	biological process	anion transport
			cellular component	integral to membrane
				integral to plasma membrane
				membrane
				membrane fraction
			molecular function	anion exchanger activity
				antiporter activity
				inorganic anion exchanger activity
2.91954	up	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	biological process	apoptosis
				response to stress
				RNA splicing
			cellular component	nucleus
			molecular function	DNA binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.