MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	Gene Ontology	Accession	description	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2001 to 2050 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
2.83611	down	negative regulation of cell growth	SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	biological process
		nucleus		cellular component
		positive regulation of transcription		biological process
		protein binding		molecular function
		regulation of transcription, DNA-dependent		biological process
		transcription
		transcriptional activator activity		molecular function
2.8521	up	calcium channel activity	transient receptor potential cation channel, subfamily M, member 1 [RefSeq_peptide;Acc:NP_002411]
		integral to plasma membrane		cellular component
		ion channel activity		molecular function
		ion transport		biological process
		membrane		cellular component
		membrane fraction
2.85383	down	integral to membrane	Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]
		membrane
2.86298	up	brain development	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	biological process
		DNA binding		molecular function
		ligand-dependent nuclear receptor activity
		nucleus		cellular component
		regulation of transcription, DNA-dependent		biological process
		transcription
		transcription factor activity		molecular function
2.86538		cannabinoid receptor activity	Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). [Uniprot/SWISSPROT;Acc:Q8NGS2]
		G-protein coupled receptor protein signaling pathway		biological process
		integral to membrane		cellular component
		olfactory receptor activity		molecular function
		receptor activity
		rhodopsin-like receptor activity
		sensory perception of smell		biological process
2.86965		ATP binding	RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]	molecular function
		chromosome		cellular component
		DNA binding		molecular function
		DNA topoisomerase (ATP-hydrolyzing) activity
		DNA topological change		biological process
		nucleic acid binding		molecular function
		nucleotide binding
		nucleus		cellular component
		RNA binding		molecular function
2.87038		calcium ion binding	Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]
		calpain activity
		cysteine-type endopeptidase activity
		cytoplasm		cellular component
		intracellular
		muscle development		biological process
		nucleus		cellular component
		peptidase activity		molecular function
		protein binding
		proteolysis		biological process
		response to calcium ion
		response to drug

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.