MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1043 to 1092 of 2667 in total

Regulation  : down

description	Ratio	Gene Ontology	Class
Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]	1.19212	extracellular region	cellular component
		hormone activity	molecular function
		hormone biosynthetic process	biological process
		signal transduction
		thyroid hormone generation
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	2.93895	cytoplasm	cellular component
		I-kappaB kinase/NF-kappaB cascade	biological process
		metal ion binding	molecular function
		protein binding
		signal transduction	biological process
		zinc ion binding	molecular function
Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	3.29064	chromatin binding
		DNA binding
		liver development	biological process
		metal ion binding	molecular function
		muscle development	biological process
		nucleus	cellular component
		positive regulation of transcription	biological process
		positive regulation of transcription from RNA polymerase II promoter
		protein binding	molecular function
		regulation of transcription, DNA-dependent	biological process
		RNA polymerase II transcription factor activity, enhancer binding	molecular function
		sequence-specific DNA binding
		transcription	biological process
		transcription factor activity	molecular function
		transcriptional activator activity
		zinc ion binding
Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	1.82063	integral to membrane	cellular component
		membrane
Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	1.31489	intracellular
		metal ion binding	molecular function
		protein binding
		zinc ion binding
Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	5.84607	axonogenesis	biological process
		beta-tubulin folding
		chaperone binding	molecular function
		cytoplasm	cellular component
		cytoskeleton
		microtubule
		microtubule cytoskeleton organization and biogenesis	biological process
		protein binding	molecular function
		protein folding	biological process
		protein modification process
ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	2.75593
Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	1.59763	ATP binding	molecular function
		cytoplasm	cellular component
		ligase activity	molecular function
		nucleotide binding
		protein modification process	biological process
		small conjugating protein ligase activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.