MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1901 to 1950 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
2.49031	up	protein binding	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	molecular function
		protein transport		biological process
2.4954		membrane	OMA1 homolog, zinc metallopeptidase [RefSeq_peptide;Acc:NP_660286]	cellular component
		metalloendopeptidase activity		molecular function
		metallopeptidase activity
		proteolysis		biological process
		zinc ion binding		molecular function
2.51088	down	binding	Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]
		lipid metabolic process		biological process
		structural constituent of cell wall		molecular function
		transport		biological process
		transporter activity		molecular function
2.54508	up	cell adhesion	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]	biological process
		cell-cell adhesion
		cholinesterase activity		molecular function
		integral to membrane		cellular component
		intercellular junction maintenance		biological process
		membrane		cellular component
		neurexin binding		molecular function
		postsynaptic membrane		cellular component
		synapse
		synaptogenesis		biological process
2.57202		integral to membrane	Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]	cellular component
		membrane
2.58329	down	calcium ion binding	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	molecular function
		cell differentiation		biological process
		metal ion binding		molecular function
		multicellular organismal development		biological process
		nervous system development
		nucleus		cellular component
		regulation of transcription, DNA-dependent		biological process
		transcription
		transcription factor activity		molecular function
		zinc ion binding
2.61135		DNA damage response, detection of DNA damage	28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]	biological process
		mitochondrial small ribosomal subunit		cellular component
		mitochondrion
		peptide biosynthetic process		biological process
		ribonucleoprotein complex		cellular component
2.65068	up	calcium ion binding	NULL	molecular function
		complement activation		biological process
		extracellular region		cellular component
		proteolysis		biological process
		serine-type endopeptidase activity		molecular function
2.69364		anterior/posterior pattern formation	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	biological process
		central nervous system development
		electron transport
		endoplasmic reticulum		cellular component
		heme binding		molecular function
		iron ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.