MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 18 to 67 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.1243	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	nucleic acid binding	molecular function
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		transcription
		zinc ion binding	molecular function
1.13541	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	blood coagulation	biological process
		calcium ion binding	molecular function
		cell adhesion	biological process
		extracellular region	cellular component
		membrane
		protein binding	molecular function
		regulation of growth	biological process
		structural molecule activity	molecular function
		transmembrane receptor activity
1.14311	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	cytoplasm	cellular component
		insulin-like growth factor receptor binding	molecular function
		negative regulation of protein kinase activity	biological process
		protein domain specific binding	molecular function
		protein kinase C binding
		protein kinase C inhibitor activity
		protein targeting	biological process
		regulation of neuron differentiation
		regulation of signal transduction
		regulation of synaptic plasticity
1.1611	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	electron carrier activity	molecular function
		electron transport	biological process
		enzyme activator activity	molecular function
		extracellular region	cellular component
		guanylate cyclase activator activity	molecular function
		hormone activity
		signal transduction	biological process
1.17859	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]	integral to membrane	cellular component
		membrane
1.18096	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	anagen	biological process
		blood pressure regulation
		caveolar membrane	cellular component
		cell motility	biological process
		cyclooxygenase pathway
		cytoplasm	cellular component
		electron transport	biological process
		endoplasmic reticulum	cellular component
		fatty acid biosynthetic process	biological process
		heme binding	molecular function
		iron ion binding
		membrane	cellular component
		metal ion binding	molecular function
		microsome	cellular component
		negative regulation of cell proliferation	biological process
		nucleus	cellular component
		oxidoreductase activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.