MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1505 to 1554 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.25808	chromatin binding	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]	molecular function
	chromatin modification		biological process
	circulation
	DNA binding		molecular function
	embryonic hindlimb morphogenesis		biological process
	female genitalia development
	heart morphogenesis
	helicase activity		molecular function
	hydrolase activity
	in utero embryonic development		biological process
	inner ear morphogenesis
	locomotory behavior
	nose development
	nucleic acid binding		molecular function
	nucleotide binding
	nucleus		cellular component
	palate development		biological process
	positive regulation of body size
	regulation of transcription, DNA-dependent
	sensory perception of sound
	transcription
1.2734	calcium channel regulator activity	Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	molecular function
	calcium ion binding
	cell adhesion		biological process
	integral to membrane		cellular component
	membrane
	neurotransmitter secretion		biological process
	protein binding		molecular function
	synaptic transmission		biological process
	synaptogenesis
1.27516	microtubule cytoskeleton	Uncharacterized protein C16orf48. [Uniprot/SWISSPROT;Acc:Q9H0I2]	cellular component
1.28319	autophagy	Autophagy-related protein 10 (APG10-like). [Uniprot/SWISSPROT;Acc:Q9H0Y0]	biological process
	cytoplasm		cellular component
	intracellular
	positive regulation of protein modification		biological process
	protein amino acid lipidation
	protein binding		molecular function
	protein transport		biological process
	ubiquitin cycle
1.28514	calcium ion binding	EF-hand domain-containing protein C17orf57. [Uniprot/SWISSPROT;Acc:Q8IY85]	molecular function
1.28698	mRNA processing	THO complex subunit 2 (Tho2). [Uniprot/SWISSPROT;Acc:Q8NI27]	biological process
	mRNA transport
	nucleus		cellular component
	RNA binding		molecular function
	RNA splicing		biological process
	transport
1.29151	binding	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]	molecular function
	cell cycle		biological process
	cell division
	cytoplasm		cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.