MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	Accession	description	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1501 to 1550 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.72656	protein serine/threonine phosphatase activity	down	protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	molecular function
	response to hydrogen peroxide			biological process
	response to oxidative stress
1.73211	ATP binding		Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	molecular function
	cell cycle			biological process
	cell proliferation
	chromosome, pericentric region			cellular component
	condensed chromosome
	cytoplasm
	meiosis			biological process
	nucleolus			cellular component
	nucleotide binding			molecular function
	nucleus			cellular component
	protein binding			molecular function
	regulation of progression through cell cycle			biological process
1.73291	membrane	up	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	cellular component
	potassium ion transport			biological process
	protein binding			molecular function
	voltage-gated potassium channel activity
	voltage-gated potassium channel complex			cellular component
1.74736	cytoplasm	down	Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]
	membrane
1.75026	axon ensheathment	up	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	biological process
	calcium-independent cell-cell adhesion
	cell adhesion
	cell junction			cellular component
	identical protein binding			molecular function
	integral to membrane			cellular component
	membrane
	spermatogenesis			biological process
	structural molecule activity			molecular function
	tight junction			cellular component
1.75846	amino acid metabolic process	down	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	biological process
	integral to membrane			cellular component
	L-cystine transport			biological process
	L-cystine transporter activity			molecular function
	lysosomal membrane			cellular component
	lysosome
	membrane
	transport			biological process
1.76583	aminopeptidase activity		leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	molecular function
	antigen processing and presentation of endogenous peptide antigen via MHC class I			biological process
	blood pressure regulation
	endoplasmic reticulum lumen			cellular component
	membrane alanyl aminopeptidase activity			molecular function
	metallopeptidase activity
	N-terminal arginine aminopeptidase activity
	N-terminal lysine aminopeptidase activity
	proteolysis			biological process
	zinc ion binding			molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.