MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1453 to 1502 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.66679	up	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	molecular function	nucleic acid binding
				protein binding
				transferase activity, transferring glycosyl groups
				zinc ion binding
1.683	down	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	biological process	rRNA processing
			cellular component	cytoplasm
				exosome (RNase complex)
				nucleus
			molecular function	exonuclease activity
				GDP-dissociation stimulator activity
				hydrolase activity
				ribonuclease activity
				RNA binding
1.69153		Keratin-associated protein 19-2. [Uniprot/SWISSPROT;Acc:Q3LHN2]	cellular component	intermediate filament
1.693		CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]	biological process	metabolic process
			molecular function	catalytic activity
				iron-sulfur cluster binding
1.69345	up	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]	biological process	regulation of transcription
				regulation of transcription, DNA-dependent
			cellular component	nucleus
			molecular function	DNA binding
				RNA polymerase II transcription factor activity
				transcription factor activity
1.69658	down	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]	biological process	protein amino acid glycosylation
			cellular component	Golgi apparatus
				integral to Golgi membrane
				integral to membrane
				membrane
			molecular function	beta-galactoside alpha-2,3-sialyltransferase activity
				sialyltransferase activity
				transferase activity, transferring glycosyl groups
1.69856	up	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	biological process	neuromuscular synaptic transmission
				protein amino acid phosphorylation
			cellular component	cytoplasm
			molecular function	ATP binding
				calmodulin binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
1.72628	down	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]	biological process	DNA repair
			cellular component	integral to membrane
				membrane
			molecular function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
				structural molecule activity
1.72656		protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	biological process	ER overload response
				response to hydrogen peroxide
				response to oxidative stress
			cellular component	protein phosphatase type 1 complex

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.