MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1355 to 1404 of 2667 in total

Regulation  : up

Ratio	description	Gene Ontology	Class
1.19496	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]	tricarboxylic acid cycle	biological process
1.19539	Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]	amino acid metabolic process
		catalytic activity	molecular function
		cysteine desulfurase activity
		cytoplasm	cellular component
		cytosol
		lyase activity	molecular function
		metabolic process	biological process
		mitochondrion	cellular component
		nucleus
		protein complex assembly	biological process
		pyridoxal phosphate binding	molecular function
		sulfur amino acid metabolic process	biological process
		transaminase activity	molecular function
		transferase activity
1.19545	Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	apoptosis	biological process
		deoxyribonuclease II activity	molecular function
		DNA binding
		DNA catabolic process	biological process
		DNA metabolic process
		endodeoxyribonuclease activity	molecular function
		endonuclease activity
		erythrocyte differentiation	biological process
		extracellular region	cellular component
		hormone activity	molecular function
		hydrolase activity
		lysosome	cellular component
		multicellular organismal development	biological process
		protein binding	molecular function
1.20102	Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]	apoptosis	biological process
		cell cycle
		copper ion binding	molecular function
		electron transport	biological process
		endosome	cellular component
		FAD binding	molecular function
		ferric-chelate reductase activity
		integral to membrane	cellular component
		ion transport	biological process
		iron ion binding	molecular function
		iron ion transport	biological process
		membrane	cellular component
		metal ion binding	molecular function
		oxidoreductase activity
		plasma membrane	cellular component
1.21657	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	cell cycle	biological process
		cytokinesis
		GTP binding	molecular function
		GTPase activity
		nucleotide binding
		plasma membrane	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.