MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1301 to 1350 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.17879	ion channel activity	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	molecular function
	ion transport		biological process
	membrane		cellular component
	membrane fraction
	potassium ion binding		molecular function
	potassium ion transport		biological process
	sensory perception of sound
	voltage-gated ion channel activity		molecular function
	voltage-gated potassium channel activity
	voltage-gated potassium channel complex		cellular component
1.18263	growth factor binding	Fibroblast growth factor-binding protein 3 precursor (FGF-binding protein 3) (FGF-BP3) (FGFBP-3). [Uniprot/SWISSPROT;Acc:Q8TAT2]	molecular function
1.18489	cGMP biosynthetic process	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	biological process
	cyclic nucleotide biosynthetic process
	cytoplasm		cellular component
	guanylate cyclase activity		molecular function
	heme binding
	intracellular signaling cascade		biological process
	iron ion binding		molecular function
	metal ion binding
	phosphorus-oxygen lyase activity
1.18711	protein binding	NULL
1.19117	cytoplasm	Ras-related GTP-binding protein D (Rag D). [Uniprot/SWISSPROT;Acc:Q9NQL2]	cellular component
	G-protein coupled receptor protein signaling pathway		biological process
	GTP binding		molecular function
	guanyl nucleotide binding
	nucleotide binding
	nucleus		cellular component
	protein binding		molecular function
	signal transducer activity
	transport		biological process
1.19207	cytoplasm	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Uniprot/SWISSPROT;Acc:Q9GZY0]	cellular component
	intracellular
	mRNA export from nucleus		biological process
	multicellular organismal development
	nuclear RNA export factor complex		cellular component
	nucleotide binding		molecular function
	nucleus		cellular component
	protein binding		molecular function
	RNA binding
	transport		biological process
1.19496	carbohydrate metabolic process	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]
	cytoplasm		cellular component
	cytosol
	glutathione metabolic process		biological process
	glyoxylate cycle
	isocitrate dehydrogenase (NADP+) activity		molecular function
	isocitrate metabolic process		biological process
	magnesium ion binding		molecular function
	manganese ion binding
	metabolic process		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.