MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1268 to 1317 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.57088	up	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]	molecular function	nucleic acid binding
				protein homodimerization activity
				sequence-specific DNA binding
				transcription factor activity
				zinc ion binding
1.58045	down	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]	biological process	peroxisome organization and biogenesis
			cellular component	integral to peroxisomal membrane
				integral to plasma membrane
				membrane
				peroxisomal membrane
				peroxisome
			molecular function	protein binding
1.58115	up	Tetratricopeptide repeat protein 18 (TPR repeat protein 18). [Uniprot/SWISSPROT;Acc:Q5T0N1]		binding
1.59177		Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]	biological process	actomyosin structure organization and biogenesis
				muscle development
			molecular function	actin binding
				protein binding
1.59188		Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Uniprot/SWISSPROT;Acc:Q8TF68]	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	intracellular
				nucleus
			molecular function	DNA binding
				metal ion binding
				nucleic acid binding
				zinc ion binding
1.59763	down	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	biological process	protein modification process
				ubiquitin cycle
			cellular component	cytoplasm
			molecular function	ATP binding
				ligase activity
				nucleotide binding
				small conjugating protein ligase activity
				ubiquitin-protein ligase activity
1.59819	up	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]	biological process	detection of stimulus during sensory perception
				protein amino acid dephosphorylation
				response to stimulus
				visual perception
			molecular function	calcium ion binding
				hydrolase activity
				iron ion binding
				manganese ion binding
				phosphoprotein phosphatase activity
				protein serine/threonine phosphatase activity
1.60668		Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]	biological process	calcium ion homeostasis
				calcium ion transport
				ion transport
				osmosensory signaling pathway
				regulation of cell volume
				response to mechanical stimulus
			cellular component	integral to membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.