MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Gene Ontology	Regulation	description	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1251 to 1300 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.55809	endoplasmic reticulum	down	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Uniprot/SWISSPROT;Acc:Q14442]	cellular component
	GPI anchor biosynthetic process			biological process
	phosphatidylinositol N-acetylglucosaminyltransferase activity			molecular function
	protein modification process			biological process
	transferase activity, transferring glycosyl groups			molecular function
1.55844	intracellular signaling cascade	up	TP53-target gene 5 protein (TP53-inducible gene 5 protein). [Uniprot/SWISSPROT;Acc:Q9Y2B4]	biological process
	molecular_function			molecular function
	negative regulation of cell growth			biological process
1.56335	metal ion binding		Zinc finger SWIM domain-containing protein 3. [Uniprot/SWISSPROT;Acc:Q96MP5]	molecular function
	zinc ion binding
1.57088	caudate nucleus development		Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]	biological process
	intracellular			cellular component
	metal ion binding			molecular function
	nucleic acid binding
	nucleus			cellular component
	protein homodimerization activity			molecular function
	putamen development			biological process
	regulation of transcription, DNA-dependent
	sequence-specific DNA binding			molecular function
	transcription			biological process
	transcription factor activity			molecular function
	zinc ion binding
1.58045	integral to peroxisomal membrane	down	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]	cellular component
	integral to plasma membrane
	membrane
	peroxisomal membrane
	peroxisome
	peroxisome organization and biogenesis			biological process
	protein binding			molecular function
1.58115	binding	up	Tetratricopeptide repeat protein 18 (TPR repeat protein 18). [Uniprot/SWISSPROT;Acc:Q5T0N1]
1.59177	actin binding		Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]
	actomyosin structure organization and biogenesis			biological process
	muscle development
	protein binding			molecular function
1.59188	DNA binding		Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Uniprot/SWISSPROT;Acc:Q8TF68]
	intracellular			cellular component
	metal ion binding			molecular function
	nucleic acid binding
	nucleus			cellular component
	regulation of transcription, DNA-dependent			biological process
	transcription
	zinc ion binding			molecular function
1.59763	ATP binding	down	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]
	cytoplasm			cellular component
	ligase activity			molecular function
	nucleotide binding
	protein modification process			biological process
	small conjugating protein ligase activity			molecular function
	ubiquitin cycle			biological process
	ubiquitin-protein ligase activity			molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.