MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1501 to 1550 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2). [Uniprot/SWISSPROT;Acc:Q9H1P3]	2.43098	up	biological process	lipid transport
				steroid metabolic process
Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	4.55371			G-protein signaling, coupled to cyclic nucleotide second messenger
				signal transduction
				skeletal development
			cellular component	cytoplasm
				integral to membrane
				integral to plasma membrane
				membrane
				nucleus
			molecular function	G-protein coupled receptor activity
				parathyroid hormone receptor activity
				receptor activity
PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	5.81102		cellular component	cell surface
				cytoplasm
				cytoskeleton
				nucleus
			molecular function	metal ion binding
				protein binding
				zinc ion binding
Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]	1.58045	down	biological process	peroxisome organization and biogenesis
			cellular component	integral to peroxisomal membrane
				integral to plasma membrane
				membrane
				peroxisomal membrane
				peroxisome
			molecular function	protein binding
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Uniprot/SWISSPROT;Acc:Q14442]	1.55809		biological process	GPI anchor biosynthetic process
				protein modification process
			cellular component	cytoplasm
				endoplasmic reticulum
			molecular function	phosphatidylinositol N-acetylglucosaminyltransferase activity
				transferase activity, transferring glycosyl groups
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]	5.23046		biological process	G-protein coupled receptor protein signaling pathway
				negative regulation of apoptosis
				phosphoinositide phosphorylation
				phosphoinositide-mediated signaling
				protein amino acid phosphorylation
			cellular component	phosphoinositide 3-kinase complex
			molecular function	1-phosphatidylinositol-3-kinase activity
				inositol or phosphatidylinositol kinase activity
				phosphatidylinositol-4,5-bisphosphate 3-kinase activity
				phosphotransferase activity, alcohol group as acceptor
				protein binding
				transferase activity
Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	1.17693	up	biological process	biological_process
			cellular component	cellular_component
				cytoplasm
				membrane
			molecular function	lipid binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.