MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Accession	Ratio	Gene Ontology	Regulation	description	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 118 to 167 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.15279	integral to plasma membrane	up	Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]	cellular component
	membrane
	protein binding			molecular function
	structural molecule activity
	viral capsid			cellular component
1.1611	electron carrier activity	down	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	molecular function
	electron transport			biological process
	enzyme activator activity			molecular function
	extracellular region			cellular component
	guanylate cyclase activator activity			molecular function
	hormone activity
	signal transduction			biological process
1.16158	calcium channel activity	up	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	molecular function
	calcium ion transport			biological process
	ion channel activity			molecular function
	ion transport			biological process
	membrane			cellular component
1.16173	nucleic acid binding		oligonucleotide/oligosaccharide-binding fold containing 2B [RefSeq_peptide;Acc:NP_076973]	molecular function
1.16363	integral to membrane		Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Uniprot/SWISSPROT;Acc:Q9HBV2]	cellular component
	membrane
1.16393	G-protein coupled receptor protein signaling pathway		olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]	biological process
	integral to membrane			cellular component
	olfactory receptor activity			molecular function
	rhodopsin-like receptor activity
1.16499	cell adhesion		ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	biological process
	central nervous system development
	integral to membrane			cellular component
	integrin binding			molecular function
	membrane			cellular component
	metalloendopeptidase activity			molecular function
	negative regulation of cell adhesion			biological process
	protein binding			molecular function
	proteolysis			biological process
	zinc ion binding			molecular function
1.16823	cell proliferation		S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]	biological process
	G1/S transition of mitotic cell cycle
	protein binding			molecular function
	regulation of progression through cell cycle			biological process
	ubiquitin cycle
1.16921	cell differentiation		Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]
	DNA binding			molecular function
	multicellular organismal development			biological process
	nervous system development
	nucleus			cellular component
	regulation of transcription			biological process
	regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription cofactor activity			molecular function
	transcription factor activity
	transcription factor complex			cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.