MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1155 to 1204 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.49271	down	Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]	cellular_component	cellular component
			DNA repair	biological process
			molecular_function	molecular function
			protein binding
			ubiquitin cycle	biological process
1.49444	up	Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	ligase activity	molecular function
			protein modification process	biological process
			small conjugating protein ligase activity	molecular function
			ubiquitin cycle	biological process
			ubiquitin-protein ligase activity	molecular function
1.49558	down	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	BMP signaling pathway	biological process
			bone mineralization
			cardiac cell differentiation
			cartilage development
			cell fate commitment
			cell growth
			cell-cell signaling
			cytokine activity	molecular function
			embryonic development	biological process
			epithelial to mesenchymal transition
			extracellular region	cellular component
			extracellular space
			growth	biological process
			growth factor activity	molecular function
			inflammatory response	biological process
			negative regulation of cell proliferation
			negative regulation of progression through cell cycle
			odontogenesis (sensu Vertebrata)
			organ morphogenesis
			osteoblast differentiation
			positive regulation of astrocyte differentiation
			positive regulation of ossification
			positive regulation of osteoblast differentiation
			protein binding	molecular function
			regulation of transcription	biological process
			transforming growth factor beta receptor binding	molecular function
			ureteric bud branching	biological process
1.49923		Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	blood vessel development
			cell-cell adhesion
			guanyl-nucleotide exchange factor activity	molecular function
			intracellular	cellular component
			platelet-derived growth factor receptor signaling pathway	biological process
			protein binding	molecular function
			regulation of small GTPase mediated signal transduction	biological process
			signal transduction
			small GTPase mediated signal transduction
			transmembrane receptor protein tyrosine kinase signaling pathway
1.50206	up	LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]	ceramide biosynthetic process
			endoplasmic reticulum	cellular component
			integral to membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.