MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1118 to 1167 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.48363	down	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291]	biological process	mitosis
				protein amino acid phosphorylation
				regulation of progression through cell cycle
			cellular component	nucleus
			molecular function	ATP binding
				magnesium ion binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
1.48389		Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]	biological process	ATP synthesis coupled proton transport
				intracellular protein transport across a membrane
				mRNA transport
				protein transport
			cellular component	intracellular
				nuclear pore
				nucleus
				proton-transporting two-sector ATPase complex
			molecular function	ATP binding
				DNA binding
				hydrogen ion transporting ATP synthase activity, rotational mechanism
				hydrogen ion transporting ATPase activity, rotational mechanism
				metal ion binding
				protein binding
				transporter activity
				zinc ion binding
1.49264	up	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]	biological process	electron transport
			cellular component	endoplasmic reticulum
				membrane
			molecular function	heme binding
				iron ion binding
				metal ion binding
				monooxygenase activity
				oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
1.49271	down	Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]	biological process	cell cycle
				DNA repair
				ubiquitin cycle
			cellular component	cellular_component
			molecular function	molecular_function
				protein binding
1.49444	up	Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	biological process	protein modification process
				ubiquitin cycle
			molecular function	ligase activity
				small conjugating protein ligase activity
				ubiquitin-protein ligase activity
1.49558	down	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	biological process	BMP signaling pathway
				bone mineralization
				cardiac cell differentiation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.