MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Accession	Class	Gene Ontology	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1069 to 1118 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.45148	up	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]	biological process	vesicle-mediated transport
			cellular component	ER-Golgi intermediate compartment
				Golgi apparatus
				Golgi membrane
				Golgi stack
				integral to membrane
				membrane
				nucleus
			molecular function	DNA binding
				protein binding
1.45314		NULL		DNA binding
1.45624		Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]	biological process	circulation
				hemostasis
				multicellular organismal development
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
			cellular component	nucleus
			molecular function	DNA binding
				protein dimerization activity
				sequence-specific DNA binding
				transcription coactivator activity
				transcription factor activity
1.45635		Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]	biological process	cell cycle
				cell division
				mitosis
				mitotic G2 checkpoint
				positive regulation of transcription
				regulation of cyclin-dependent protein kinase activity
				regulation of progression through cell cycle
			cellular component	cytoplasm
				female pronucleus
				male pronucleus
				nucleus
			molecular function	protein binding
1.4628		Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Uniprot/SWISSPROT;Acc:Q9NQS3]	biological process	cell adhesion
				homophilic cell adhesion
			cellular component	apical junction complex
				cell-cell adherens junction
				integral to membrane
				plasma membrane
			molecular function	protein binding
				protein homodimerization activity
				receptor activity
1.47697		Nck-associated protein 1-like (Membrane-associated protein HEM-1) (Hematopoietic protein 1). [Uniprot/SWISSPROT;Acc:P55160]	cellular component	integral to plasma membrane
				membrane
				membrane fraction
1.48363	down	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291]	biological process	cell cycle
				cell division
				mitosis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.