MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
4.4149	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	regulation of transcription, DNA-dependent	biological process
		sequence-specific DNA binding	molecular function
		transcription	biological process
		transcription factor activity	molecular function
4.49282	Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	chromatin modification	biological process
		negative regulation of gene expression, epigenetic
		negative regulation of transcription from RNA polymerase II promoter
		nuclear membrane	cellular component
		nucleoplasm
		nucleus
		positive regulation of transcription from RNA polymerase II promoter	biological process
		regulation of cell growth
		regulation of transcription, DNA-dependent
		transcription
		transcriptional activator activity	molecular function
		transcriptional repressor activity
4.49844	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	extracellular space	cellular component
		hormone activity	molecular function
4.50619	Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	apoptosis	biological process
		cytoplasm	cellular component
		cytoskeleton
		membrane
		phagocytosis	biological process
4.62042	Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	integral to membrane	cellular component
		integral to plasma membrane
		membrane
		plasma membrane
		protein amino acid N-linked glycosylation	biological process
		visual perception
4.69231	Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245]	acetyltransferase activity	molecular function
		arylamine N-acetyltransferase activity
		cytoplasm	cellular component
		metabolic process	biological process
		transferase activity	molecular function
4.71132	Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	cellular_component	cellular component
		glycolysis	biological process
		magnesium ion binding	molecular function
		potassium ion binding
		pyruvate kinase activity
		response to other organism	biological process
		transferase activity	molecular function
4.90535	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]	protein binding
4.93372	Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	intracellular signaling cascade	biological process
5.23046	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]	1-phosphatidylinositol-3-kinase activity	molecular function
		G-protein coupled receptor protein signaling pathway	biological process
		inositol or phosphatidylinositol kinase activity	molecular function
		negative regulation of apoptosis	biological process
		phosphatidylinositol-4,5-bisphosphate 3-kinase activity	molecular function
		phosphoinositide 3-kinase complex	cellular component
		phosphoinositide phosphorylation	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.