MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.40749	up	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]	cellular component	integral to membrane
			molecular function	dopamine receptor activity
				extracellular matrix structural constituent
				structural constituent of cell wall
				structural molecule activity
1.41851	down	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]	biological process	MAPKKK cascade
				nervous system development
				transmembrane receptor protein tyrosine kinase signaling pathway
			molecular function	insulin receptor binding
				transmembrane receptor protein tyrosine kinase signaling protein activity
1.42215		Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	biological process	monoamine transport
				neurotransmitter transport
				neurotransmitter uptake
				serotonin transport
			cellular component	integral to plasma membrane
				membrane
			molecular function	monoamine transporter activity
				neurotransmitter:sodium symporter activity
				protein binding
				serotonin transporter activity
				serotonin:sodium symporter activity
				symporter activity
1.42264	up	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]	biological process	homoiothermy
				mRNA processing
				response to freezing
				RNA splicing
				translation
				type I hypersensitivity
			cellular component	cytoplasm
				intracellular
				nucleus
				ribosome
			molecular function	ice binding
				metal ion binding
				nucleic acid binding
				nucleotide binding
				RNA binding
				structural constituent of ribosome
				zinc ion binding
1.43088	down	Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	biological process	carotenoid biosynthetic process
				cholesterol biosynthetic process
				isoprenoid biosynthetic process
			cellular component	peroxisome
			molecular function	hydrolase activity
				isomerase activity
				isopentenyl-diphosphate delta-isomerase activity
				magnesium ion binding
1.43351		Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]	biological process	proteolysis
				vacuolar protein catabolic process
			molecular function	carboxypeptidase A activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.