MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Accession	Gene Ontology	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 101 to 150 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.19212	Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]	extracellular region	cellular component
		hormone activity	molecular function
		hormone biosynthetic process	biological process
		signal transduction
		thyroid hormone generation
1.20481	Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]	biological_process
		cellular_component	cellular component
		cytoplasmic vesicle
		generation of precursor metabolites and energy	biological process
		growth factor activity	molecular function
		neuropeptide hormone activity
		ovarian follicle development	biological process
		sexual reproduction
1.20619	Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	ATP binding	molecular function
		ATP hydrolysis coupled proton transport	biological process
		ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	molecular function
		catalytic activity
		cation transport	biological process
		GABA-B receptor activity	molecular function
		hydrogen ion homeostasis	biological process
		hydrolase activity	molecular function
		hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
		integral to membrane	cellular component
		magnesium ion binding	molecular function
		membrane	cellular component
		metabolic process	biological process
		monovalent inorganic cation transport
		monovalent inorganic cation transporter activity	molecular function
		nucleotide binding
		potassium ion binding
		potassium ion transport	biological process
		proton transport
		sodium ion binding	molecular function
		sodium ion transport	biological process
		sodium:potassium-exchanging ATPase activity	molecular function
		sodium:potassium-exchanging ATPase complex	cellular component
		sperm motility	biological process
		transport
1.20924	Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]	3-chloroallyl aldehyde dehydrogenase activity	molecular function
		alcohol metabolic process	biological process
		aldehyde dehydrogenase [NAD(P)+] activity	molecular function
		cytoplasm	cellular component
		embryonic eye morphogenesis	biological process
		lipid metabolic process
		metabolic process
		nucleus accumbens development
		optic cup morphogenesis involved in camera-type eye development
		oxidoreductase activity	molecular function
		positive regulation of apoptosis	biological process
		retinoic acid metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.