MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Accession	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 101 to 150 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.14311	down	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	insulin-like growth factor receptor binding	molecular function
			negative regulation of protein kinase activity	biological process
			protein domain specific binding	molecular function
			protein kinase C binding
			protein kinase C inhibitor activity
			protein targeting	biological process
			regulation of neuron differentiation
			regulation of signal transduction
			regulation of synaptic plasticity
1.14915	up	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]	cell-cell signaling
			integral to membrane	cellular component
			membrane
			receptor binding	molecular function
			signal transduction	biological process
			transport
1.15279		Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]	cell adhesion
			glycosaminoglycan binding	molecular function
			integral to plasma membrane	cellular component
			membrane
			protein binding	molecular function
			structural molecule activity
			viral capsid	cellular component
1.1611	down	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	electron carrier activity	molecular function
			electron transport	biological process
			enzyme activator activity	molecular function
			extracellular region	cellular component
			guanylate cyclase activator activity	molecular function
			hormone activity
			signal transduction	biological process
1.16158	up	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	calcium channel activity	molecular function
			calcium ion transport	biological process
			ion channel activity	molecular function
			ion transport	biological process
			membrane	cellular component
1.16173		oligonucleotide/oligosaccharide-binding fold containing 2B [RefSeq_peptide;Acc:NP_076973]	nucleic acid binding	molecular function
1.16363		Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Uniprot/SWISSPROT;Acc:Q9HBV2]	integral to membrane	cellular component
			membrane
1.16393		olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]	G-protein coupled receptor protein signaling pathway	biological process
			integral to membrane	cellular component
			olfactory receptor activity	molecular function
			rhodopsin-like receptor activity
1.16499		ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	cell adhesion	biological process
			central nervous system development
			integral to membrane	cellular component
			integrin binding	molecular function
			membrane	cellular component
			metalloendopeptidase activity	molecular function
			negative regulation of cell adhesion	biological process
			protein binding	molecular function
			proteolysis	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.