Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation Gene Ontology description Accession Class Gene Minimum Ratio Maximum Ratio
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Showing element 1 to 50 of 2667 in total
Ratio	Regulation	Gene Ontology	description	Class	
1.07618	up	G-protein coupled receptor protein signaling pathway	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	biological process	
1.07618	up	integral to membrane	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	cellular component	
1.07618	up	metal ion binding	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	molecular function	
1.07618	up	nucleic acid binding	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	molecular function	
1.07618	up	nucleotide binding	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	molecular function	
1.07618	up	nucleus	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	cellular component	
1.07618	up	rhodopsin-like receptor activity	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	molecular function	
1.07618	up	ribonucleoprotein complex	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	cellular component	
1.07618	up	RNA binding	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	molecular function	
1.07618	up	RNA splicing	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	biological process	
1.07618	up	U12-dependent spliceosome	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	cellular component	
1.07618	up	zinc ion binding	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	molecular function	
1.08658	down	protein binding	pyrin and HIN domain family, member 1 alpha 1 isoform [Source:RefSeq_peptide;Acc:NP_689714]	molecular function	
1.10233	up	cell cycle arrest	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Source:Uniprot/SWISSPROT;Acc:Q99501]	biological process	
1.10233	up	cytoplasm	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Source:Uniprot/SWISSPROT;Acc:Q99501]	cellular component	
1.10233	up	cytoskeleton	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Source:Uniprot/SWISSPROT;Acc:Q99501]	cellular component	
1.10831	up	collagen binding	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Source:Uniprot/SWISSPROT;Acc:Q15113]	molecular function	
1.10831	up	multicellular organismal development	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Source:Uniprot/SWISSPROT;Acc:Q15113]	biological process	
1.10867	up	adenohypophysis development	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	cell-cell signaling	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	elevation of cytosolic calcium ion concentration	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	extracellular region	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	cellular component	
1.10867	up	G-protein signaling, adenylate cyclase activating pathway	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	growth hormone secretion	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	growth hormone-releasing hormone activity	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	molecular function	
1.10867	up	growth hormone-releasing hormone receptor binding	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	molecular function	
1.10867	up	hormone activity	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	molecular function	
1.10867	up	positive regulation of body size	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	positive regulation of cAMP metabolic process	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	positive regulation of growth hormone secretion	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	positive regulation of hormone secretion	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	positive regulation of transcription	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	signal transduction	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	biological process	
1.10867	up	terminal button	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	cellular component	
1.10889	up	cytoplasm	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	cellular component	
1.10889	up	nucleus	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	cellular component	
1.10889	up	protein dimerization activity	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	molecular function	
1.10889	up	regulation of transcription, DNA-dependent	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	biological process	
1.10889	up	sequence-specific DNA binding	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	molecular function	
1.10889	up	transcription	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	biological process	
1.10889	up	transcription factor activity	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	molecular function	
1.11083	down	integral to plasma membrane	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	cellular component	
1.11083	down	membrane	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	cellular component	
1.11083	down	neurotransmitter transport	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	biological process	
1.11083	down	neurotransmitter:sodium symporter activity	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	molecular function	
1.11083	down	plasma membrane	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	cellular component	
1.11083	down	symporter activity	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	molecular function	
1.11083	down	transporter activity	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	molecular function	
1.11519	up	cytoplasm	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [Source:RefSeq_dna;Acc:NM_001099408]	cellular component	
1.11519	up	RNA binding	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [Source:RefSeq_dna;Acc:NM_001099408]	molecular function	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.
- http://analysis.yellowcouch.org/